Elsewhere, Wolfsburg and Augsburg shared the spoils after playing out a goalless stalemate. Enditem
United had a dream start when Bruno Fernandes scored a second minute penalty, but soon dropped behind as Tanguy Ndombele and then Son Heung-min netted for Spurs.
Tsitsipas was edged by Stan Wawrinka in a marathon over-fiver-hour battle at this stage last year, but this time he took chances with his 24 winners against the No.18 seed.
The evening featured 20 performances. Tong Jian told reporters that 26 athletes took part in the event, which was the largest performance their team had participated in. Several movie stars and celebrities were in attendance to get a first glimpse of the festivities.
Madrid boss Zinedine Zidane, who has to work out what his most effective line up without the injured Eden Hazard is, could start with Wednesday's goal scorer, Vinicius Jr alongside Karim Benzema and Marco Asensio.
"We had a poor start as our players didn't show enough mentality, but I'm satisfied with the players' performance in the following three quarters," Shaanxi coach Jiang E'Ying commented.
James' free kick was headed home by Yerry Mina on the stroke of halftime to put Everton back in front, before James rounded off an excellent individual display with two second-half goals.
Leeds United and Manchester City producing a thrilling 1-1 draw which lived up to expectations in terms of entertainment and suspect defending.
Rodriguez and Falcao were among 18 Europe-based players included in the 24-man squad announced by the Colombian Football Federation on Friday.
Meanwhile, Sport Recife won 2-1 at Bahia, their third successive Serie A victory. Hernane and Marcao were on the scoresheet for the visitors while Matheus Saldanha netted for Bahia.
After substitutes stepped in, Xinjiang maintained its level of defense, holding Shanghai to shot-clock violations on several occasions and leading 27-18 at halftime.